Abstract
A series of methoxycarbonyl group modified nidulalin A analogs were synthesized to improve stability against esterases. The amide derivatives showed cytotoxic activity along with inhibitory activity against DNA topoisomerase II. Among the analogs, amide 9a exhibited antitumor activity in Colon 26 murine tumor model.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Drug Screening Assays, Antitumor
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Mice
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Topoisomerase II Inhibitors*
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Tumor Cells, Cultured
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Xanthines / chemical synthesis*
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Xanthines / chemistry
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Xanthines / pharmacology*
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Topoisomerase II Inhibitors
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Xanthines